Table 1 |.

Examples of IFN responses to NANPs with various physicochemical properties

	Amount detected (pg/ml)
Supernatant	Donor 1		Donor 2		Donor 3
IFN-α
Untreated	BLOQ	BLOQ	BLOQ	BLOQ	BLOQ	BLOQ
ODN2216	29,287	28,034	16,963	15,605	15,179	13,193
L2K	BLOQ	BLOQ	BLOQ	BLOQ	BLOQ	BLOQ
DNA cube/L2K	4,889	4,602	2,375	2,262	4,198	5,121
RNA cube/L2K	25,530	19,965	17,564	17,204	14915	15,091
RNA ring/L2K	6,937	5,985	4,552	5,721	9,398	7,531
IFN-β
Untreated	BLOQ	BLOQ	BLOQ	BLOQ	BLOQ	BLOQ
ODN2216	141	118	82	82	69	BLOQ
L2K	BLOQ	BLOQ	BLOQ	BLOQ	162	BLOQ
DNA cube/L2K	BLOQ	BLOQ	BLOQ	BLOQ	162	BLOQ
RNA cube/L2K	450	343	369	311	362	299
RNA ring/L2K	64	BLOQ	77	BLOQ	132	BLOQ
IFN-ω
Untreated	BLOQ	BLOQ	BLOQ	BLOQ	BLOQ	12.4
ODN2216	1,254	1,209	738	774	633	607
L2K	BLOQ	BLOQ	BLOQ	BLOQ	BLOQ	BLOQ
DNA cube/L2K	201	202	118	105	214	231
RNA cube/L2K	875	730	623	587	599	686
RNA ring/L2K	194	223	132	178	290	291
IFN-λ
Untreated	BLOQ	BLOQ	BLOQ	BLOQ	BLOQ	BLOQ
ODN2216	729	764	BLOQ	BLOQ	BLOQ	BLOQ
L2K	BLOQ	BLOQ	BLOQ	BLOQ	BLOQ	BLOQ
DNA cube/L2K	BLOQ	BLOQ	BLOQ	BLOQ	BLOQ	BLOQ
RNA cube/L2K	887	698	382	417	600	482
RNA ring/L2K	BLOQ	BLOQ	146	BLOQ	147	146

BLOQ, below the lower limit of quantification. The data are reproduced with permission from ref.²⁵, American Chemical Society. Each value in the table represents an independent sample tested in duplicate on an ELISA plate and is the mean of two responses (%CV <25).