Table 1.
Box-Behnken design used for optimization of VCZ-loaded ultradeformable elastosomal formulae.
| Factors (independent variables) | Levels |
||
|---|---|---|---|
| (−1) | (0) | (+1) | |
| X1: PC: EA weight ratio | 1:1 | 2.5:1 | 4:1 |
| X2: Percentage of hyaluronic acid (% w/v) | 0.25 | 0.5 | 0.75 |
| X3: Percentage of polyvinyl alcohol (PVA) (%) | 1 | 3 | 5 |
| Responses (dependent variables) | Desirability constraints |
|---|---|
| Y1: Entrapment efficiency (EE) (%) | Maximize |
| Y2: Particle size (PS) (nm) | Minimize |
| Y3: Zeta potential (ZP) (mV) | Maximize in terms of absolute value |
| Y4: Polydispersity index (PDI) | Minimize |
PC: phosphatidyl choline; EA: edge activator.