Table 5.
Effect of storage on different measurements of OE and its PVA lacking analogue.
| Parameter* | Fresh OE | Stored OE (3 months) | Fresh OE lacking PVA | Stored OE lacking PVA (3 months) |
|---|---|---|---|---|
| Drug content | 98.8 ± 0.9a | 96.7 ± 0.7a | – | – |
| Entrapment efficiency % | 72.6 ± 0.2a | 72.2 ± 0.3a | – | – |
| Particle size (nm) | 362.4 ± 10.0a | 365.5 ± 12.3a | 299.6 ± 1.3a | 293.6 ± 3.0a |
| Zeta potential (mV) | −41.7 ± 2.7a | −39.9 ± 0.1a | −37.5 ± 1.0a | −22.6 ± 1.3b |
| Polydispersity Index | 0.25 ± 0.06a | 0.28 ± 0.08a | 0.28 ± 0.00a | 0.29 ± 0.03a |
| Deformability index (g) | 12.8 ± 0.4a | 14.9 ± 0.3a | – | – |
Different superscripts indicate significant difference. Normal superscripts are used for the stored OE formula and its fresh counterpart, while bolded superscripts are reserved for the stored PVA lacking analogue and its fresh counterpart..
*Mean ± SD (n = 3).
OE: Optimal ultradeformable elastosomal formula; PVA: polyvinyl alcohol.