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. 2021 Feb 10;10(1):165–186. doi: 10.1007/s40121-020-00384-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 2 — Markers of renal function in individuals ≥ 50 years of age using F/TAF or F/TDF for PrEP (DISCOVER study) (reproduced with permission from [17]). Cr creatinine, eGFR_CG estimated glomerular filtration rate (based on the Cockcroft–Gault equation), F/TAF emtricitabine/tenofovir alafenamide, F/TDF emtricitabine/tenofovir disoproxil fumarate, PrEP pre-exposure prophylaxis, RBP retinol binding protein, β2M β2 microglobulin. Median changes from baseline in (a) eGFR_CG and (b), (c) proximal tubular protein to Cr ratios: (b) RBP:Cr ratio and (c) β2M:Cr ratio. p values at 96 weeks are derived from the Van Elteren test stratified by baseline F/TDF for PrEP to compare the two study arms