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. 2021 Feb 10;10(1):165–186. doi: 10.1007/s40121-020-00384-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 3 — BMD at 96 weeks in individuals using F/TAF or F/TDF for PrEP (DISCOVER study) (reproduced with permission from [17]). BMD bone mineral density, F/TAF emtricitabine/tenofovir alafenamide, F/TDF emtricitabine/tenofovir disoproxil fumarate, PrEP pre-exposure prophylaxis. Proportion of participants with ≥ 3% change in BMD from baseline in (a) spine and (b) hip. All p values are based on dichotomized response from Cochran–Mantel–Haenszel test for nominal data (general association statistic), adjusting for baseline F/TDF for PrEP