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. Author manuscript; available in PMC: 2021 Feb 10.
Published in final edited form as: J Med Chem. 2019 Sep 26;62(19):8866–8872. doi: 10.1021/acs.jmedchem.9b00936

Scheme 1. Synthesis of fluorinated MAGL inhibitorsa.

Scheme 1.

aReagents and conditions: (i) TFA, rt, 1 h; (ii) (R)-1,1,1-trifluoro-3-(4-methoxybenzyloxy)propan-2-ol, 1,1’-[carbonylbis(oxy)]di-pyrrolid-ine-2,5-dione, Et3N, CH2Cl2, 30 °C, 30 h; (iii) TFA, CH2Cl2, rt, 4 h; 34% yield for 6; 35% yield for 7; 22% yield for 8; 18% yield for 9; 31% yield for 10.