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. Author manuscript; available in PMC: 2021 Feb 10.
Published in final edited form as: J Med Chem. 2019 Sep 26;62(19):8866–8872. doi: 10.1021/acs.jmedchem.9b00936

Scheme 2. Synthesis of MAGL PET probe 13 ([18F]6)a.

Scheme 2.

aReagents and conditions: (i) mCPBA, CHCl3, rt, 12 h; (ii) SPIAd, 10% Na2CO3, EtOH, rt, 4 h; 35% yield over 2 steps. (iii) [18F]Et4NF, DMF, 120 °C, 10 min; (iv) 6 N HCl, 100 °C, 4 min, 8% non-decay corrected RCY.