FIG. 7.

TBI does not alter spontaneous synaptic transmission or endocannabinoid signaling 11 days post-TBI in alcohol-naïve animals. Whole-cell patch clamp slice electrophysiology was performed on BLA pyramidal neurons from alcohol-naïve Sham and TBI animals 11 days post-TBI in Expt. 3. There were no differences in sEPSC frequency (A) or amplitude (B) nor were there changes in sIPSC frequency (C) or amplitude (D). There were also no differences in depolarization-induced suppression of excitation (DSE; E) or inhibition (DSI; F). Data were analyzed via two-tailed t test or Mann Whitney test, *p < 0.05, **p < 0.01, n = 15–30 cells/group, n = 6–9 animals/group. Data are expressed as mean ± SEM. BLA, basolateral amygdala; SEM, standard error of the mean; sEPSC, spontaneous excitatory post-synaptic current; sPSC, spontaneous inhibitory post-synaptic current; TBI, traumatic brain injury.