Table 1.
Experimental Groups, Conditions, and Outcomes
| Groups | Treatment | Outcome measures | |
|---|---|---|---|
| Experiment 1 | Alcohol-naïve Sham | Craniotomy | Post-TBI physiological measures, alcohol SA (drinkers), EPM, BLA eCB proteins |
| Alcohol-naïve TBI | Craniotomy, TBI | ||
| Alcohol-drinking Sham | Operant conditioning, craniotomy | ||
| Alcohol-drinking TBI | Operant conditioning, craniotomy, TBI | ||
| Experiment 2 | Alcohol-naïve Sham | Craniotomy | Post-TBI physiological measures, BLA eCB levels |
| Alcohol-naïve TBI | Craniotomy, TBI | ||
| Alcohol-drinking Sham | Operant conditioning, craniotomy | ||
| Alcohol-drinking TBI | Operant conditioning, craniotomy, TBI | ||
| Experiment 3 | Alcohol-naïve Sham | Craniotomy | BLA slice electrophysiology |
| Alcohol-naïve TBI | Craniotomy, TBI |
BLA, basolateral amygdala; eCB, endocannabinoid; EPM, elevated plus maze; SA, self-administration; TBI, traumatic brain injury.