Table 2.
Percentage of maximal relaxation (Rmax) to acetylcholine, sodium nitroprusside, and salbutamol and maximal contraction (Emax) to calcium ionophore and phenylephrine in mesenteric arteries of experimental rats.
| Groups | Endothelium-dependent responses | Smooth muscle responses | ||||
|---|---|---|---|---|---|---|
| Acetylcholine | Calcium ionophore | Sodium nitroprusside | Salbutamol | Phenylephrine | ||
| NR |
R
max (%) Emax (%) |
74.56 (18.53) | 27.19 (22.64) | 69.30 (16.39) | 91.12 (9.10) | 118.50 (40.31) |
| DC |
R
max (%) Emax (%) |
53.48 (19.97)a | 58.78 (25.59) a | 67.83 (22.11) | 91.98 (6.58) | 148.30 (63.77) |
| DD |
R
max (%) Emax (%) |
28.45 (10.70)a,b | 97.55 (20.80)a,b | 34.42 (9.44)a,b | 86.28 (15.44) | 141.50 (36.15) |
| DDS |
R
max (%) Emax (%) |
48.40 (8.41)a,c | 90.67 (29.14)a,b | 52.24 (16.04) | 90.92 (17.34) | 168.70 (72.90) |
Data are presented as mean (SD), n = 10 rats, ap < 0.05 vs NR, bp < 0.05 vs DC, cp < 0.05 vs DD [NR: nondiabetic rats with control diet; DC: diabetic rats with control diet; DD: diabetic rats with vitamin D-deficient diet; DDS: diabetic rats with vitamin D-deficient diet+calcitriol supplementation].