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. Author manuscript; available in PMC: 2021 Feb 10.
Published in final edited form as: J Med Chem. 2020 Apr 9;63(12):6513–6522. doi: 10.1021/acs.jmedchem.9b01849

Table 2.

Experiment Used to Test Orteronel Inhibition Kinetic Mechanism (Table 1, Figure 10).a

(add equal volume)
T1 period (90 s) T2 period (300 s)
[E]: 0.08 μM [I]: 0, 2, or 6 μM
[S]: 20 μM
a

E: P450 17A1, S: progesterone, I: orteronel.