Table 2.

Overview of collected variables.

Collection period	Category	Variable		Unit(s) or categories
Collected before visit of late-effects clinic	Childhood cancer type and treatment	Primary childhood cancer diagnosis		ICCC-3a classification
		Treatment protocol		Name and arm
		Chemotherapy, per regimen		TCDb
		Radiotherapy field
			Cranial/craniospinal		TCD, fractions (if applicable)
			Total body		TCD, fractions (if applicable)
			Abdominal		TCD, fractions (if applicable)
			Pancreas involvement		TCD, fractions (if applicable)
		Surgery procedure
			Autologous stem cell transplantation		Yes / No, conditioning regimen
			Allogeneic stem cell transplantation		Yes / No, conditioning regimen
		Relapse		Yes / No
	Patient characteristics	Sex		Male / Female
		Date of birth		Date
		Date of childhood cancer diagnosis		Date
		Date of study measurements (follow-up date)		Date
	Medical history	Height at cancer diagnosis		Centimeter
		Weight at cancer diagnosis		Kilogram
		Growth hormone deficiency		Yes / No
		Growth hormone replacement		Yes / No
		Hypothyroidism		Yes / No
		Hypogonadism		Yes / No
		Hypocortisolism with steroid replacement		Yes / No
Collected at visit of late-effects clinic	Physical examination	Height		Centimeter
		Weight		Kilogram
		Waist circumference		Centimeter
		Hip circumference		Centimeter
		Blood pressure		mmHg
	General health questionnaire	Does the survivor have or has the survivor experienced
			High cholesterol		Yes / No, age at diagnosis
			Hypertension		Yes / No, age at diagnosis
			Diabetes mellitus		Yes / No, age at diagnosis
			Myocardial infarction		Yes / No, age at diagnosis
			Stroke		Yes / No, age at diagnosis
		Medication use		Type, dose, age at start
		Smoking status		Yes / Former / No
		Cardiovascular disease in family		Relative, type of disease, age at diagnosis
	Questionnaire to Assess Health enhancing physical activity	N/Ac		N/A
	Dual-energy x-ray absorptiometry scan	Total body fat		Percentage
		Z-score total body fat		Z-score
		Lean body mass		Kilogram per m2
		Appendicular lean body mass		Kilogram per m2
	6-minute walking test	N/A		Meter
	Data determined from stored samples	Serum biomarkers
			High-density lipoprotein		mmol/L
			Low-density lipoprotein		mmol/L
			Total cholesterol		mmol/L
			Apolipoprotein-B		g/L
			Glucose		mmol/L
			Insulin		pmol/L
			Adiponectin		ug/mL
			Leptin		ng/mL
			Uric acid		mmol/L
			High sensitivity C-reactive protein		mg/L
			IL-6d		pg/mL
			hsTNFae		pg/mL
			IL-1f		pg/mL
			IGF-1g		ug/L
			Creatinine		mg/mmol
			Urea		mmol/L
			LHh		U/L
			FSHi		U/L
			AMHj		ug/L
			Estradiol		pmol/L
			Testosterone		nmol/L
		DNA from blood/saliva		N/A

^aICCC-3: International Classification of Childhood Cancer, edition 3.

^bTCD: total cumulative dose.

^cN/A: not applicable.

^dIL-6: interleukin-6.

^ehsTNF: high-sensitivity tumor necrosis factor alpha.

^fIL-1: interleukin-1.

^gIGF-1: insulin-like growth factor 1.

^hLH: luteinizing hormone.

ⁱFSH: follicle stimulating hormone.

^jAMH: anti-Müllerian hormone.