Figure 1.

A display of genome compositional dynamics of SARS-CoV-2

A. The complete genome sequence of SARS-CoV-2 (GenBank: NC_045512.2), including both structural and non-structural components. B. We use a 300-nt sliding window with a 21-nt step to show dynamic changes of genomic G + C, purine, and G + C contents at three codon positions (denoted as GC1, GC2, and GC3) as well as GC skews (G-C/G + C) over the entire genome. C. A similar procedure as described above is applied to individual ORFs and proteins. Note that GC skews are not uniform over the genome length and the ORFs based plots are not in the same scale as what for the genome-wide GC skews. D. Mean G + C and purine contents of SARS-CoV-2 genome, individual ORFs and proteins.