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. 2021 Feb 3;590(7845):300–307. doi: 10.1038/s41586-020-03145-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — Tree constructed from complete-linkage hierarchical clustering of Jaccard similarity matrix of enhancer activity across biosamples. Fifty subtrees covering the full tree are annotated with their major subgroups. Tree is cut and coloured to create 20 clusters for purposes of visualization. Leaves are labelled with metadata and reduced sample names and coloured according to their tissue group. Metadata (heat map track) from inside-out: tissue group, project, sample type, and donor sex and life stage.