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. 2020 Nov 11;151(2):257–265. doi: 10.1007/s11060-020-03660-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Survival after radiosurgery stratified according to prognostic scores. a The estimated survival after GKRS1 was significantly longer in patients with NLR < 5 (75/170, 44%; 11.3 months, 95% CI = 7.0–15.5) than in patients with NLR ≥ 5 (95/170, 56%; 3.3 months, 95% CI = 1.8–4.7; p < 0.001). b The estimated survival after GKRS1 was significantly longer in patients with PLR < 180 (69/170, 41%; 10.9 months, 95% CI = 6.9–14.8) than in patients with PLR ≥ 180 (101/170, 59%; 4.3 months, 95% CI = 3.1–5.6; p = 0.003). c The estimated survival after GKRS1 was significantly longer in patients with LMR ≥ 4 (26/170, 15%; 12.9 months, 95% CI = 9.3–16.5) than in patients with LMR < 4 (144/170, 85%; 4.7 months, 95% CI = 3.8–5.6, p = 0.023). d Patients with a mGPS score of 0 (23/49, 47%) showed the longest estimated median survival after GKRS1 with 11.8 months (95% CI = 0.2–23.3), followed by patients with mGPS of 1 (14/49, 29%) with 4.6 months (95% CI = 0.0–10.4), and mGPS of 2 (12/49, 24%) with 1.9 months (95% CI = 1.4–2.4; p < 0.001). Additional pairwise comparisons revealed significant differences in survival between mGPS scores 0 and 2 (p < 0.001) and between mGPS scores 1 and 2 (p = 0.022), even after Shaffer correction for multiple testing. Patients with a mGPS score of 0 only showed a tendency towards a longer survival after GKRS1 compared to patients with a mGPS score of 1 (p = 0.075). Thus, patients with poor mGPS scores, defined as mGPS 1 and 2, were pooled together. The comparison between mGPS score of 0 (23/49, 47%; 11.8 months; 95% CI = 0.2–23.3) and pooled mGPS score of 1 and 2 (26/49, 53%; 2.2 months; 95% CI = 1.2–3.2) additionally revealed significant differences in survival after GKRS1 (p = 0.002). CI confidence interval, GKRS Gamma Knife Radiosurgery, LMR Lymphocyte-to-Monocyte-Ratio, mGPS modified Glasgow Prognostic Score. NLR Neutrophil-to-Lymphocyte Ratio, PLR Platelet-to-Lymphocyte-Ratio