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. 2021 Feb 10;12(2):173. doi: 10.1038/s41419-021-03435-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A The relative levels of core proteins in the hedgehog pathway were evaluated in cells with LINC01426 knockdown. B The relative mRNA levels of SHH, Gli1, and Gli2 was evaluated by RT-qPCR. One-way ANOVA. One-way ANOVA. C The luciferase activity of SHH promoter was determined in cells transfected with shRNAs targeting LINC01426. One-way ANOVA. D, E The level of SHH protein was measured in PC-9 and Calu3 cells transfected with sh/LINC01426#1 after treatment with CHX for different time points. F SHH protein level in PC-9 and Calu3 cells treated with MG132 after transfected with sh/Ctrl or sh/LINC01426#1. G The ubiquitination level of SHH protein in PC-9 and Calu3 cells transfected with sh/LINC01426#1 or sh/Ctrl. n.s. no significance.