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. 2021 Feb 10;12(2):173. doi: 10.1038/s41419-021-03435-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Pull-down sliver staining assay and spectrometry analysis assessed the potential proteins combined with LINC01426. B Pull-down and western blot analysis revealed the interaction between USP22 and LINC01426. C RIP assay examined the enrichment of LINC01426 in the anti-USP22 group and anti-IgG. One-way ANOVA. D, E The binding of SHH and USP22 was disrupted by LINC01426. F, G. The level of SHH or USP22 protein was detected in LINC01426-silenced PC-9 and Calu3 cells after treatment with CHX for different time points. H SHH protein was detected in USP22-silenced PC-9 and Calu3 cells treated with MG132. I Ubiquitination assay was used to detecting SHH ubiquitination in PC-9 and Calu3 cells transfected with sh/LINC01426#1 after treated with MG132. ^**P < 0.01.