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. 2021 Feb 10;11:3461. doi: 10.1038/s41598-021-83019-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of the development anti-SARS-CoV-2 RBD and NP antibodies. Peripheral blood was collected from hospitalized COVID-19 and recovered patients. Negative samples were obtained from true SARS-CoV-2 negative patients (i.e., prior to the SARS-CoV-2 pandemic). Plasma was obtained, diluted 1:50, and added to a 96-well plate precoated with SARS-CoV-2 RBD (a–c) or NP (d–f) antigens. IgG (a,d), IgM (b,e), and IgA (c,f) levels are shown. (a–f) Kinetics of all samples. Data were calculated using GraphPad Prism 8; the dotted line represents the calculated cutoff values (95% and 98% sensitivity) discriminating between positive and negative samples. Statistical analysis was performed using a Nonparametric Kruskal–Wells test for multiple comparisons.