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. 2021 Jan 28;13:573966. doi: 10.3389/fnagi.2021.573966

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Copyright © 2021 Tsumagari, Maruo, Nakao, Ueda, Yamanoue and Shirai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Motor dyscoordination in SAMP8 at 24 weeks old. (A,B) Motor coordination of SAMR1 and SAMP8 at 6 weeks old (A) and 24 weeks old (B) was assessed by the accelerating rotarod test. The test was performed three times daily for 2 days (6W SAMR1: n = 6; 6W SAMP8: n = 6; 24W SAMR1: n = 12; 24W SAMP8: n = 12) Statistical analysis was conducted by one-way ANOVA for repeated measure (Day 1 24W SAMR1 vs. 24W SAMP8: **p < 0.01, Day 1 trials: **p < 0.01, Day 2 24W SAMR1 vs. 24W SAMP8: **p < 0.01). (C) Motor coordination of SAMR1 and SAMP8 at 24 weeks old mice was assessed by the number of hind paw slips in the beam test. The test was performed five times daily for 2 days (24W SAMR1: n = 9; 24W SAMP8: n = 9); **p < 0.01 followed by Student’s t-test. Data are expressed as mean ± SEM.