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. 2021 Feb 10;7:31. doi: 10.1038/s41420-021-00404-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A RT-qPCR and western blot were used to detect the levels of IP3R1 in the myocardium of rats after MI/R and shRNA intervention; B TTC staining was used to detect the infarct size of MI/R rats. AAR/LV reflects the degree of ischemia, INF/AAR reflects the degree of infarction, n = 3; C HE staining was used to observe the pathological changes of myocardium of MI/R rats, n = 6. D the effect of IP3R1 on the concentration of myocardial enzymes in MI/R rats, n = 21; E immunohistochemical observation of GSDMD-positive expression, n = 6; F colorimetric method was used to detect the activity of Caspase-1, n = 6; G Western blot detected the levels of NLRP3, ASC, and GSDMD-N, n = 6; H ELISA was used to measure the levels of IL-1β and IL-18, n = 6; compared with the sham group, ***p < 0.001; for pairwise comparison, ^###p < 0.001. Data in panels A/B/D/F were analyzed using one-way ANOVA and data in panels G/H were analyzed using two-way ANOVA. Tukey’s multiple comparison test was applied for the post hoc test after ANOVA.