Table V.
Biological pathways enriched for genes with expression levels correlated with GSDMB expression in BEC in the longitudinal cohort
| Pathway | Gene | P value (FDR) |
|---|---|---|
| Interferon gamma signaling | CIITA, HLA-A, HLA-B, HLA-C, HLA-F, IFNG, IFNGR2, IL20RA, IRF9, MID1, OAS2, OAS3, PML, SP110, SP140L, STAT 1, SUMO1, TRIM14, TRIM22, TRIM25, TRIM26, TRIM38 | 2.3E-14 |
| Interferon alpha/beta signaling | BST2, HLA-A, HLA-B, HLA-C, HLA-F, IFI27, IRF9, MX2, OAS2, OAS3, STAT1, STAT2, USP18, XAF1 | 2.3E-14 |
| Antigen Presentation (Folding, assembly and peptide loading of class I MHC) | HLA-A, HLA-B, HLA-C, HLA-F, SEC24B, TAP1, TAP2, TAPBP | 2.3E-14 |
| ER-Phagosome pathway | HLA-A, HLA-B, HLA-C, HLA-F, IKBKB, PSMB9, PSMD8, PSME2, RAPSN, TAP1, TAP2, TAPBP | 2.3E-14 |
| Interferon Signaling | BST2, CIITA, HLA-F, IFI27, IFNG, IFNGR2, IL20RA, IRF9, MAPK1, MID1, MX2, NUP210, OAS2, OAS3, PML, SP110, SP140L, STAT1, STAT2, SUMO1, TRIM14, TRIM22, TRIM25, TRIM26, TRIM38, UBA7, USP18, XAF1 | 2.3E-14 |
| Endosomal/Vacuolar pathway | HLA-A, HLA-B, HLA-C, HLA-F | 2.3E-14 |
| Antigen processing-Cross presentation | HLA-A, HLA-B, HLA-C, HLA-F, IKBKB, ITGB5, PSMB9, PSMD8, PSME2, RAPSN, TAP1, TAP2, TAPBP | 2.3E-14 |
| Class I MHC mediated antigen processing & presentation | ASB14, ASB4, ASB8, FBXL3, FBXO2, FBXO21, FBXO41, HLA-A, HLA-B, HLA-C, HLA-F, IKBKB, ITGB5, NARF, PJA2, POLL, PSMB9, PSMD8, PSME2, RAPSN, RBX1, RNF213, SEC24B, SIAH1, SKP1, TAP1, TAP2, TAPBP, TRIM36, TRIM39, UBA7, UBE2D2, UBE2D4, UBE2E3 | 3.5E-13 |
| Immunoregulatory interactions (between a Lymphoid and a non-Lymphoid cell) | CD226, CLEC2D, HLA-A, HLA-B, HLA-C, HLA-F, RAET1E | 6.3E-11 |
| Cytokine Signaling in Immune system | ATF1, ATF2, CALM2, CIITA, CRKL, DUSP16, FASLG, HLA-A, HLA-B, HLA-C, HLA-F, IFI27, IKBKB, IL18BP, IL20RA, IL37, IL6ST, IRF9, LAMTOR3, LGALS9, LIFR, MID1, MX2, NDN, PDGFA, PML, PSME2, PTPN14, PTPN4, RBX1, SKP1, SP110, STAT1, STAT2, STAT6, TRIM14, TRIM22, TRIM25, TRIM26, TRIM38 | 7.9E-08 |
| Adaptive Immune System | ACTR10, ASB4, ASB8, ASB14, BLNK, BTF3, BTN2A1, BTN2A2, BTN3A1, CALM2, CARD11, CD74, CLEC2D, DCTN3, DCTN6, FBXL3, FBXO41, GRAP2, HLA-A, HLA-B, HLA-C, IKBKB, MAP3K14, POLL, PSMD8, RAET1E, SEC24B, SIAH1, SKP1, TAP1, TAP2, TBCB, TEP1, TRIM36, TRIM39, UBA7, UBE2D2, UBE2D4, UBE2E3, ZAP70 | 9.7E-03 |
Note: pathways with false discovery rate (FDR)-adjusted p-value less than 0.05 were included.