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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Prog Retin Eye Res. 2020 Aug 11;82:100897. doi: 10.1016/j.preteyeres.2020.100897

Figure 2.

Figure 2.

A pair of human eyes was perfused at 1X (top panel) or 2X pressure (bottom panel) for 48 hours. Tissues were fixed, radial paraffin sections were cut and immunostained with an ADAMTS4 polyclonal antibody (red). ADAMTS4 is reduced in the corneoscleral TM but becomes highly upregulated in the juxtacanalicular (JCT) region of the TM tissue in 2X pressure. The immunostaining is also more punctate in 2X tissue compared to 1x tissue. Green = autofluorescence. SC= Schlemm’s canal. Scale bar = 20 μm. (Keller et al., 2009b)