Table 1.
Characteristics of patients at ICU admission
| N (%) or Median (IQR) | All n = 26 |
Survivors in ICU n = 6 |
Non survivors in ICU n = 20 |
P value |
|---|---|---|---|---|
| Demographics | ||||
| Age (years) | 38 [26–57] | 28 [34–35] | 44 [28–58] | 0.26 |
| Male gender | 13 (50) | 3 (50) | 10 (50) | 1.00 |
| Hematological malignancy | 0.78 | |||
| Acute leukemia | 13 (50) | 3 (50) | 10 (50) | |
| - ALL | 7 | 2 | 5 | |
| - AML | 6 | 1 | 5 | |
| Lymphoma | 5 (20) | 1 (17) | 4 (20) | |
| - Hodgkin | 1 | 0 | 1 | |
| - Non-Hodgkin | 4 | 1 | 3 | |
| Aplastic anemia | 4 (15) | 1 (17) | 3 (15) | |
| Othera | 4 (15) | 1 (17) | 3 (15) | |
| Status of HM | 0.41 | |||
| Recently diagnosed | 8 (31) | 3 (50) | 5 (25) | |
| At least partial response | 11 (42) | 1 (17) | 10 (50) | |
| Progression | 5 (19) | 2 (33) | 3 (15) | |
| Unknown | 2 (8) | 0 | 2 (10) | |
| Previous treatments | ||||
| Allogeneic SCT | 9 (35) | 0 | 9 (45) | 0.12 |
| Steroids during the last 3 months | 16 (62) | 5 (83) | 11 (55) | 0.52 |
| Antifungal prophylaxis | 7 (27) | 3 (50) | 4 (22) | 0.44 |
| Reason for ICU admission | 0.15 | |||
| Acute respiratory failure | 14 (53) | 2 (33) | 12 (60) | |
| Shock | 5 (19) | 3 (50) | 2 (10) | |
| Perioperative management | 3 (12) | 0 | 3 (15) | |
| Coma | 1 (4) | 0 | 1 (5) | |
| Acute kidney injury | 1 (4) | 0 | 1 (5) | |
| Otherb | 2 (8) | 1 (17) | 1 (5) | |
| Biological tests | ||||
| Creatinine (µmol/L) | 84 [49–119] | 76 [56–90] | 86 [45–123] | 0.46 |
| Albumin (g/L) | 26 [23–31] | 28 [24–30] | 25 [23–30] | 0.85 |
| Bilirubin (µmol/L) | 25.9 [15.0–43.0] | 25.1 [17.1–30.8] | 25.9 [12.7–46.5] | 1.00 |
| Leukocytes (G/L) | 0.22 [0.10–2.60] | 0.58 [0.21–1.06] | 0.20 [0.10–4.30] | 0.85 |
| Hemoglobin (g/dL) | 8.4 [7.9–9.1] | 8.0 [7.1–9.5] | 8.5 [8.0–9.0] | 0.50 |
| Platelets (G/L) | 25 [13–42] | 17 [6–30] | 26 [14–41] | 0.24 |
| Prothrombin (%) | 70 [50–76] | 56 [48–73] | 71 [58–75] | 0.55 |
| SOFA score | 7 [5–8] | 6 [5–6] | 7 [5.5–9.5] | 0.18 |
| Treatments in the ICU | ||||
| Mechanical ventilation | 21 (81) | 1 (17) | 20 (100) | < 0.001 |
| Vasopressors | 18 (69) | 3 (50) | 15 (75) | 0.51 |
| Renal replacement therapy | 9 (35) | 0 | 9 (45) | 0.12 |
ICU intensive care unit, ALL acute lymphoblastic leukemia, AML acute myeloid leukemia, HM hematological malignancy, SCT stem cell transplantation, SOFA score Sepsis-related Organ Failure Assessment
aMyelodysplastic syndrome, chronic myeloid leukemia, hairy cell leukemia and hemophagocytic syndrome
bIncluding diabetic ketoacidosis and monitoring