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. 2021 Jan 28;11:618992. doi: 10.3389/fphar.2020.618992

FIGURE 3.

FIGURE 3

Kir6.2 deficiency prevents dopaminergic neurons loss and behavioral deficits in LPS-induced mouse models for PD. (A) Microphotographs of Cresyl violet-positive cells in the SNc. (B)Stereological counts of Cresyl violet-positive cells in the SNc. (C) Representative IHC staining of TH-positive neurons in midbrain sections. (D) Protein levels of TH in brain lysates were analyzed by immunoblotting analysis. (E) Stereological counts of TH-positive neurons in the SNc. (F) Densitometric analysis of TH. (G) Turning time (T-turn) of the mice in the pole test. (H) Total climbing time of the mice in the pole test. (I) Latency to fall of the mice in the rotarod test. Data were analyzed by two-way ANOVA. *p < 0.05, **p < 0.01, and ***p < 0.001 vs. the saline group of the same genotype. # p < 0.05, ## p < 0.01 and ### p < 0.01 vs. the LPS group of the WT mice. n = 6 mice per group for IHC and Nissl staining. n = 3 for western blotting. n = 12 mice for behavioral tests. Values are presented as means ± SEM.