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Schematic graph of astrocytic kir6.2 in promoting neurotoxic A1 astrocyte formation. Abnormal expression of kir6.2 in activated astrocytes induced by inflammatory stimuli orchestrates the formation of neurotoxic A1 astrocyte phenotype by promoting Drp1-mediated excessive mitochondrial fission and subsequent mitochondrial malfunctions, including MMP loss, energy supply shortage and oxidative stress.
