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. 2021 Jan 28;8:577125. doi: 10.3389/fcell.2020.577125

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Copyright © 2021 Luo, Chen, Zhang, Huang, Zhao, Zhao, Li, Zhou, Liu, Cai and Bi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MEIS1 identified as transcription factors of immune prognostic model (IPM) genes in metastatic colorectal cancer (mCRC). (A) Putative transcription factors involved in regulating IPM genes expression; only MEIS1 showed a positive correlation with SLIT2 and CLU expression and a negative correlation with CDKN2A simultaneously (P < 0.05). (B) Decreased MEIS1 level associated with worse progression-free survival (PFS) (HR < 0.55, P = 0.005). (C) MEIS1 level was significantly downregulated in the tumor tissue relative to the solid tissue normal (P < 0.001). (D) Expression of MEIS1 has a negative association with MEIS1 methylation (P < 0.05). (E) MEIS1 methylation was more in tumor than the normal tissue in colon cancer (P < 0.001).