Figure 4.

(A) The local immune status may confer an intense immune phenotype in the IPM-low-risk group and a weakened immune phenotype in the IPM-high-risk group. (B) Within and between groups, the proportion of immune cells in metastatic colorectal cancers (mCRCs) varies. Therefore, variations in the proportions of tumor-infiltrating immune cells might represent an intrinsic feature that could characterize individual differences. (C) Proportions of some subpopulations of tumor-infiltrating immune cells are correlated. (D) The samples of IPM low- and high-risk mCRCs patients clearly separated into two discrete groups based on principal component analysis, indicating that two groups are distinctly different in immune infiltrating cells. (E) IPM high-recurrence risk mCRCs are at immunosuppression status. (F) The Estimation of Stromal and Immune cells in Malignant Tumor tissues Using Expression Data (ESTIMATE) algorithm showing that the stroma and immune cells infiltration in IPM high-risk groups are less than those in the low-risk group. (G) The IPM high-risk mCRCs have significantly higher proportions of Tregs and lower proportions of resting memory CD4+ T cells.