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. 2021 Jan 28;13:623751. doi: 10.3389/fnagi.2021.623751

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Copyright © 2021 Boltze, Aronowski, Badaut, Buckwalter, Caleo, Chopp, Dave, Didwischus, Dijkhuizen, Doeppner, Dreier, Fouad, Gelderblom, Gertz, Golubczyk, Gregson, Hamel, Hanley, Härtig, Hummel, Ikhsan, Janowski, Jolkkonen, Karuppagounder, Keep, Koerte, Kokaia, Li, Liu, Lizasoain, Ludewig, Metz, Montagne, Obenaus, Palumbo, Pearl, Perez-Pinzon, Planas, Plesnila, Raval, Rueger, Sansing, Sohrabji, Stagg, Stetler, Stowe, Sun, Taguchi, Tanter, Vay, Vemuganti, Vivien, Walczak, Wang, Xiong and Zille.

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Proposed model for a combinatorial therapy in intracerebral hemorrhage (ICH). (A) Minimally invasive surgery for the evacuation of the hematoma (primaryintervention). (B) Minimally invasive surgery offers the particular opportunity to deliver potential therapeutics (cell transplantation, biomaterials/scaffolds, neuroprotective, and/or immunomodulatorydrugs) as secondary intervention directly into the lesion site, reducing drug delivery issues and potential systemic side effects of the drugs.