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Schematic overview of Klotho structure and cleavage. Membrane-bound Klotho consists of four main domains, being the signal sequence (SS), KL1, KL2, and the transmembrane domain (TM). Several sheddases can cut this membrane-bound Klotho forming full-length soluble Klotho (α-cut) or KL1 and KL2 soluble Klotho (both α- and β-cut). Illustrated sequences reflect the suggested cleavage sites at which these cuts occur. Figure is created with BioRender.com.
