Table 1.

Klotho mouse models for renal and cardiovascular diseases.

	Mouse model	Reported outcome	References
Klotho in renal disease	Aged Klotho+/− mice	Impaired kidney function with glomerulosclerosis, interstitial fibrosis and increased albuminuria	(39, 40)
	UUO in Klotho+/− mice	Exacerbated kidney fibrosis	(41)
	UUO in Klotho tg mice UUO in Klotho+/− mice	Reduced tubulointerstitial fibrosis Enhanced tubulointerstitial fibrosis	(44)
	Recombinant Klotho treatment in UUO	Alleviation of UUO-induced EndoMT, reduced fibrosis, and improved kidney function	(48)
	Bilateral IRI in Klotho+/− mice IRI in Klotho tg mice Recombinant Klotho treatment after AKI in mice or rats	Faster progression to CKD Improved preservation of kidney function after AKI Accelerated recovery and reduced renal fibrosis	(29, 42)
	Adenoviral delivery of Klotho in rats with IRI	Reduced renal damage	(46)
	ICR-derived glomerulonephritis in Klotho transgenic mice	Improved renal function and survival	(43)
Klotho in cardiovascular complications	Klotho+/− mice or tg mice with uni-Nx with IRI in contralateral kidney	Reduced or improved renal function and vascular calcification, respectively	(37)
	Klotho−/− mice with diabetic nephropathy AAV-mediated delivery of soluble Klotho	Hyperphosphatemia and enhanced vascular calcification Rescued phosphate levels and prevention of calcification	(45)
	Hind limb ischemia in Klotho−/− and Klotho+/− mice	Impaired angiogenesis and vasculogenesis	(50)
	Klotho−/− and Klotho+/− mice	Impaired vasodilation/vasorelaxation, rescued by parabiosis with wt mice	(51)
	Klotho+/− mice	Cardiac dysfunction, hypertrophy and fibrosis	(52)
	Klotho administration in mice with uni-Nx with IRI in contralateral kidney	Attenuated CKD-associated cardiac remodeling	(49)

AKI, acute kidney injury; CKD, chronic kidney disease; EndoMT, endothelial-to-mesenchymal transition; IRI, ischemia-reperfusion injury; Nx, nephrectomy; tg, transgenic; UUO, unilateral ureteral obstruction; wt, wild type.