Table 2.

A summary of the transient receptor potential (TRP) subtypes found in distribution of central nervous system (CNS) cell types.

PMCA subfamily	Expression in brain	Expression in glia	Disorders	References
PMCA1	- Ubiquitous in brain (human and rat). - Cerebellum, cerebral cortex, brain stem (Human)	Rat cortical astrocytes	AD, PD	Stauffer et al., 1995; Fresu et al., 1999; Brini et al., 2013
PMCA2	- Cerebellar purkinje neurons (human/mouse) - cerebellum, cerebral cortex, brain stem (Human)	Rat cortical astrocytes	AD, PD, cerebellar ataxias, sensory neuron diseases	Stauffer et al., 1995; Fresu et al., 1999; Kurnellas et al., 2007; Empson et al., 2010; Hajieva et al., 2018; Strehler and Thayer, 2018
PMCA3	- Cerebellum, cerebral cortex (Human) - Cerebellum and hippocampus (Rat)	Limited	Cerebellar ataxias, sensory neuron diseases	Stauffer et al., 1995; Zanni et al., 2012; Strehler and Thayer, 2018
PMCA4	- Ubiquitous in brain (human/rat) - Cerebellum, cerebral cortex, brain stem (Human)	Rat cortical astrocytes	AD, PD	Stauffer et al., 1995; Fresu et al., 1999; Brini et al., 2013; Zaidi et al., 2018

PMCA, plasma membrane Ca²⁺ ATPase; AD, Alzheimer's disease; PD, Parkinson's disease.