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. 2021 Jan 28;8:618228. doi: 10.3389/fcell.2020.618228

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Copyright © 2021 Lin, Zhu, Xu, Zhong, Li, Shan, Wu, Guo, Zheng, Wang, Xu, Liao, Lu, Xie and Yuan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Annexin-A2 increased in ESRD-Ex. (A–C) The content of Annexin-A2, BMP-2, and Rankl in Nor-Ex, ESRD-Ex, and RTR-Ex were measured by ELISA. (D) Western blot detected the protein levels of Annexin-A2, BMP-2, and Rankl. n = 3. (E–G) The spearman analysis showed the correlations between the content of plasma exosomes Annexin-A2, BMP-2, and Rankl with CAC total score, respectively. n = 24. *p < 0.05, compared with Nor-Ex. ns, not significant; CAC, coronary artery calcification; Nor-Ex, the plasma exosomes derived from normal health control; ESRD-Ex, the plasma exosomes derived from ESRD patients; RTR-Ex, the plasma exosomes derived from renal transplant recipients.