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. 2021 Jan 7;2(1):tgaa096. doi: 10.1093/texcom/tgaa096

Figure 3 .

Figure 3

Reelin improves the performance of the Ndel1 CKO mice in the nest building task. (A-C) Representative photographs depicting the performance of Ndel1 CKO mice injected at 5, 8, or 9 weeks of age with (A) the purified full length protein (n = 3), (B) a commercially available central active fragment of Reelin (n = 2) or (C) a control solution (n = 3). All mice were monitored for their performance after injection for up to 8 days. Red traces delimit the area with bedding material. (D) Bar graph showing the relative area with bedding material in the cage before and after control or Reelin injection in Ndel1 CKO mice. Mean ± SD, Student’s t-test, ***P < 0.001, NS: nonsignificant; n = 8 mice in total, average age: ~8 weeks; A.U.: arbitrary units. (E) Levels of Ndel1, Lis1, and GFAP in WT, Ndel1 CKO mice, and Ndel1 CKO mice injected with Reelin. Data were analyzed and compared using One-way ANOVA and Tukey’s multiple comparison test. *P < 0.05, **P < 0.01; n = 3/group.