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Study design schema. Study 1 is shown in (A). In Study 2 (B), two groups of dogs were orally administered OKV-1001b once-daily for a 15-day period. PK and PD samples were collected on Days 1, 8, and 15. On each of these days, samples were collected at pre-dose, and at 2.5, 4, and 8 h post-dose. On Day 8, additional PK samples were collected at 1, 2, and 6 h mark.
