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Bivalent modification status of genes in muscle cells in hypoxia environment, myogenetic differentiation and cellular reprogramming. In muscle cells, cellular reprograming genes and pluripotent genes are epigenetically modified with bivalent modifications (H3K4me3 and H3K27me3) and are poised for expression. Under hypoxia environment, the bivalent modifications are resolved; genes with H3K27me3 remained are silenced and genes with H3K4me3 remained are actively expressed.
