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. 2021 Jan 28;11:584937. doi: 10.3389/fimmu.2020.584937

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Copyright © 2021 Alotaibi, Vincent, Min and Koropatnick

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD5^-/low/CD4⁺ and CD5^-/low/CD8⁺ TILs have increased effector function (IFNγ, CD107a, and CD137 expression) compared to CD5^high TILs. TILs isolated from 4T1-harboring BALB/c mice were stained with fluorescence-conjugated antibodies to assess IFNγ, CD107a and CD137 in relationship with CD5. (A) The fraction of IFNγ⁺/CD5^high/CD4⁺, CD107a⁺/CD5^high/CD4⁺, CD137⁺/CD5^high/CD4⁺ vs IFNγ⁺/CD5^-/low/CD4⁺, CD107a⁺/CD5 ^-/low/CD4⁺, and CD137⁺/CD5 ^-/low/CD4⁺ TILs, respectively. (B) The fraction of IFNγ⁺/CD5^high/CD8⁺, CD107a⁺/CD5^high/CD8⁺, CD137⁺/CD5^high/CD8⁺ vs IFNγ ⁺/CD5^-/low/CD8⁺, CD107a ⁺/CD5^-/low/CD8⁺, and CD137⁺/CD5^-/low/CD8⁺ TILs, respectively. Data are shown as means ± SD of 4 or 3 mice per group and from one representative experiment of two independent experiments. *p < 0.05 (Student’s paired two-tailed t-test).