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. 2021 Jan 28;11:584937. doi: 10.3389/fimmu.2020.584937

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Copyright © 2021 Alotaibi, Vincent, Min and Koropatnick

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Both CD5^-/low/CD4⁺ and CD5^-/low/CD8⁺ TILs have increased effector function (co-expression of PD-1 and CD69). (A) The fraction of PD-1⁺/CD69⁺/CD5^-/low/CD4⁺ TILs and PD-1⁺/CD69⁺/CD5^high/CD4⁺ TILs. (B) The fraction of PD-1⁺/CD69⁺/CD5^-/low/CD8⁺ TILs and PD-1⁺/CD69⁺/CD5^high/CD8⁺ TILs. Data are shown as means ± SD of 3 mice per group and from one representative experiment of three independent experiments. *p < 0.05 (Student’s paired two-tailed t-test).