Table 4.

Statistical analysis of sleep-wake behavior parameters scaled to percent of life span, relied on comparison of regression curve slopes and intercepts.

Sleep-wake parameters	Appl Control vs. Appl DM		D42 Control vs. D42 DM*
	Slope, p-value	Intercepts, p-value	Slope, p-value	Intercepts, p-value
Daily total activity	0.4232	<0.0001	0.7117	<0.0001
Daily total sleep	0.2635	0.0004	0.0910	0.3542
Night activity offset	0.1773	0.0057	0.1415	0.6584

Statistical analysis of age-dependent changes in sleep-wake behavior parameters between DM and corresponding controls depicted in Figure 4. To compare the difference of trajectories of these changes during physiological aging, we performed comparison of regression curve slopes and intercepts using Prism GraphPad Software. Statistically significant differences are shown in bold.