FIGURE 4.

Probability of being classified into different exacerbator phenotypes over two consecutive years given a stable underlying acute exacerbation of COPD (AECOPD) rate. In line with the analysis of the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study and SubPopulations and InteRmediate OutcoMes In COPD Study (SPIROMICS) cohorts, a frequent exacerbator is defined as having ≥2 moderate/severe observed AECOPDs. For the curves that pertain to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) definition (≥2 moderate AECOPDs or ≥1 severe AECOPD) or to the American Thoracic Society (ATS) definition (≥1 moderate/severe AECOPD), please refer to the supplementary material. COPD: chronic obstructive pulmonary disease.