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. 2021 Jan 28;10:596023. doi: 10.3389/fcimb.2020.596023

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Copyright © 2021 Williams, Ly, Geraghty, McArthur, Vyas, Gorman, Tsatsaronis, Sluyter and Sanderson-Smith

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Group A Streptococcus (GAS) infection changes neutrophil functionality. Human neutrophils (PMNs) were analysed using flow cytometry, sequentially gated upon (A) ‘singlets’ (FSC-A vs. FSC-H, 10,000 events collected) then (B) viable ‘PMNs’ (FSC-A vs. FSC-H). Purified neutrophils infected with GAS were sampled over 180 min for the cell-surface expression of (C) CD11b-FITC (n=4 donors), (D) CD66b-PerCP/Cy5.5 (n=5 donors), (E) CD16-FITC (n=4 donors) and (F) CD31-PE/Cy7 (n=4 donors). Results are the pooled means ± SD. Linear mixed model ‘p’ values represent interaction (treatment*time) or are stated. *p<0.05, **p<0.01, ***p<0.001 and ****p<0.0001, with black asterisks denoting significance from control and grey asterisks between 5448 and 5448AP.