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. 2021 Jan 28;11:609490. doi: 10.3389/fimmu.2020.609490

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Copyright © 2021 Grobben, de Man, van Doornmalen, Muller, Willemsen-Seegers, Vu-Pham, Mulder, Prinsen, de Wit, Sterrenburg, van Cauter, den Ouden, van Altena, Massuger, Uitdehaag, Buijsman and Zaman

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Side-by-side comparison of biochemical and cellular activity of NTRC 3883-0 and epacadostat. (A) Immunoblot analysis of the HEK-hIDO1, HEK-hTDO, and IFNγ-stimulated A375 cell lines used for cellular assays. (B) Inhibition profile of NTRC 3883-0 and epacadostat in the hIDO1 and hTDO biochemical and HEK-293 cell-based assays.