Fig. 21.

The in vivo results of pure zinc as endovascular stent [342], copyright 2017, Elsevier Ltd. (a) Selected 2D and 3D micro-CT images of zinc stents after 0, 1, 6 and 12 months implantation. Each time point is composed of three images: the left one is a 3D reconstruction of the zinc stent, among which the white one is the residue zinc stent and the green one represents corrosion products. (b) Corrosion morphologies of zinc stents after 1 and 12 months in vivo. (c) Representative low- and high-magnification photomicrographs of hematoxylin-eosin (H&E) stained sections of abdominal aorta after 1, 3, 6, and 12 months implantation of zinc stents. The asterisk marked region at 12 months indicates the neointima without stent struts left. (d) Angiography of rabbit abdominal aorta after 12 months implantation of zinc stents. The stented segments are marked by red arrows. (e) Lumen diameter and (f) diameter stenosis of stented segments after 1, 3, 6 and 12 months implantation calculated from quantitative vessel angiography (QVA) measurements. (g) Representative immunofluorescence staining images of macrophage antibody after 3 days, 1, 3, 6 and 12 months implantation and the number of macrophages per strut at each time point. (h) Representative low- and high-magnification SEM images of endothelial coverage on zinc stents. (i) Immunohistochemical staining images of CD31 antibody and α-SMA antibody, Masson's trichrome and Verhoeffe-Van Gieson (VVG) staining images.