Table 13.

In vivo results of antibacterial pure zinc and zinc alloy.

Year	Pure Zn and Zn alloy	Animal model (position)	Application	In vivo results	[Ref.]
2015	Zn	Sprague Dawley rats (abdominal aorta)	Endovascular stent	Zn did not promote restenosis responses and might suppress the activities of inflammatory and smooth muscle cells	[341]
2017	Zn	Japanese rabbits (abdominal aorta)	Endovascular stent	No severe inflammation, platelet aggregation, thrombosis formation or obvious intimal hyperplasia was observed after 12 months post implantation (as Fig. 21).	[342]
2018	Zn and Zn-0.05 Mg	Sprague Dawley rats (bilateral tibial shaft)	load-bearing implant	Zn alloy could promote the formation of new bone tissue at the interface between the implant material and bone tissue in vivo, and the degradation had no harm to the function and histology of important organs(as Fig. 22).	[317]