| 2011 |
317L-4.5Cu |
Japanese white rabbits |
Strong antimicrobial activity, anti-inflammatory ability and strong promoting osteogenesis in vivo:
-
1)
317L-Cu screw tracts were negative for bacterial growth
-
2)
The soft-tissues and bone connected the 317L-4.5Cu screws were observed without inflammation or gross infection.
-
3)
317L-Cu implanted screws showed strong osteoid while 317L screws showed weaker osteoid growth.
-
4)
The expression of insulin-like growth factor-1 (IGF-1) in osteoblasts around 317L-4.5Cu screws tracts increased compared with 317L screws
|
[214] |
| 2014 |
317L-4.5Cu |
Sprague-Dawley rats |
Strong anti-inflammatory ability, superior bone-implant integration and promoting osteogenesis in vivo:
-
1)
No inflammation was found in the bone tissue post implantation compared with 317L.
-
2)
The Cu-containing stainless steel implant demonstrated superior bone-implant integration.
-
3)
Faster bone formation was found on the Cu-containing stainless steel samples as compared to the 317L SS.
|
[246] |
| 2016 |
317L-4.5Cu |
zebrafish embryos |
No in vivo cytotoxicity:
-
1)
The rate and time of hatching, mortality and touch response of the larval zebrafish were similar on 317L and 317L-Cu incubated samples.
-
2)
There was no malformations on embryos and larval zebrafish incubated on the 317L-Cu SS.
|
[32] |
| 2017 |
317L-4.5Cu |
Sprague-Dawley rats |
Promoting osteogenesis:
-
1)
The callus evolution efficiency and the fracture healing speed were superior for 317L-Cu
-
2)
Higher osteogenic efficiency at 6 weeks, and increased Runx2 expression were observed in the callus for 317L-Cu
-
3)
The mechanical strength of the fracture site in the case of 317L-4.5 was much better than that of the control group
|
[250] |
| 2020 |
316L-3.77Cu |
Sprague-Dawley rats |
Implant-related infection was also alleviated by 316L-Cu SS |
[212] |
