Figure 2.

Selection of compounds based on differential activity using parameters from the dose-response curve fit analysis. (A) Scatterplot of scaled values of differential (delta) maximum response (% viability at the maximum dose tested) for each compound. (B) Scatterplot of scaled values delta logIC₅₀ for each compound. (C) Scatterplot of scaled values log₂ fold change (fc) AUC for each compound. (D) Venn diagrams of hits selected based on the different parameters. In all plots and diagrams, red circles correspond to high HA22 dose treatment arm and blue circles correspond to low HA22 dose treatment arm. (E) Bar graph of the target classes enriched (−log p-value) for the 36 enhancer hits identified using the different curve class parameters. Complete list of hit compounds is included in supplemental material.