Figure 3.

Selection of compounds based on the ensemble ranking method. (A) Venn diagram of top 10% ranked enhancers (left Venn diagram) and mitigators (right Venn diagram) of HA22 cytotoxic effects. Red circles correspond to high-dose HA22 treatment arm, and blue circles correspond to low-dose HA22 treatment arm. (B) Dose responses for three top-ranked compounds by ensemble ranking method for the high- and low-dose HA22 treatment. Everolimus and IKK16 were selected as hits in both dose treatments. Solid black circles are high-dose HA22 treatment arm; open black circles are for the corresponding vehicle arm; solid red circles are low-dose HA22 treatment arm; open red circles are the corresponding vehicle arm. (C) Bar graph of the target classes enriched (−log p-value) for the 54 enhancer hits (top) and 56 mitigator hits (bottom) identified using the ensemble ranking method. Complete list of hit compounds is included in supplemental material.