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. 2021 Jan 26;24(2):102108. doi: 10.1016/j.isci.2021.102108

Figure 4.

Figure 4

Intravenous lidocaine inhibits the activation of astrocyte, but not microglia in the PFC

(A) Immunofluorescence images of microglia in PFC (bregma +2.68 mm).

(B and C) (B) Proportion of microglia-fluorescent area and (C) number of microglia in PFC, which indicated that activated microglia by RTX cannot be inhibited by lidocaine.

(D) The microglia soma sizes in PFC showed that activated microglia by RTX cannot be reversed by lidocaine.

(E) Immunofluorescence images of astrocytes in PFC (bregma +2.68 mm).

(F) Proportion of astrocyte-fluorescent area in PFC, which indicated that activated astrocytes by RTX can be reversed by lidocaine. The proportion, the number of microglia and astrocytes, and the cell soma sizes were calculated with ImageJ. Data were expressed as mean ± SEM, n = 6, 5 slices for each rat. Statistical analyses consisted of one-way ANOVA tests followed by Tukey's post-hoc tests. Scale bars, 50 μm. #p < 0.05, ##p < 0.01, ∗p < 0.05, ∗∗p < 0.01, n.s = not significant.