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. 2021 Jan 26;24(2):102108. doi: 10.1016/j.isci.2021.102108

Figure 5.

Figure 5

Intravenous lidocaine inhibits the activation of astrocyte but not microglia in ACC

(A) Immunofluorescence images of microglia in ACC (bregma +1.18 mm).

(B and C) (B) Proportion of microglia-fluorescent area and (C) number of microglia in ACC, which indicated that the activated microglia by RTX cannot be inhibited by lidocaine.

(D) The microglia soma size comparisons in ACC, which indicated that the activated microglia by RTX cannot be reversed by lidocaine.

(E) Immunofluorescence images of astrocytes in ACC (bregma +1.18 mm).

(F) Proportion of astrocyte-fluorescent area in ACC, which indicated that the activated astrocytes can be reversed by lidocaine. The proportion, the number of microglia and astrocytes, and the cell soma sizes were calculated with ImageJ. Data were expressed as mean ± SEM, n = 5–6, 5 slices for each rat. Statistical analyses consisted of one-way ANOVA tests followed by Tukey's post-hoc tests. Scale bars, 50 μm. #p < 0.05, ∗p < 0.05, n.s = not significant.