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. 2021 Jan 26;24(2):102108. doi: 10.1016/j.isci.2021.102108

Figure 7.

Figure 7

Intravenous lidocaine inhibits the activation of astrocyte but not microglia in CA3

(A) Immunofluorescence images of microglia in CA3 (bregma −1.58 mm).

(B and C) (B) Proportion of microglia-fluorescent area and (C) number of microglia in CA3, which indicated that the activated microglia cannot be inhibited by lidocaine.

(D) The microglia soma size comparisons in CA3, which indicated that the activated microglia cannot be reversed by lidocaine.

(E) Immunofluorescence images of astrocytes in CA3 (bregma −1.58 mm).

(F) Proportion of astrocyte-fluorescent area in CA3, which indicated that the activated astrocytes by RTX can be reversed by lidocaine. The proportion, number of microglia and astrocytes, and the cell soma sizes were calculated with ImageJ. Data were expressed as mean ± SEM, n = 5–6, 5 slices for each rat. Statistical analyses consisted of one-way ANOVA tests followed by Tukey's post-hoc tests. Scale bar, 50 μm. #p < 0.05, ##p < 0.01, ∗p < 0.05, ∗∗p < 0.01, n.s = not significant.