Figure 2. Subgroup Analyses: Difference in GDS-15 Score at 12 Months Between Levothyroxine and Placebo Groups.

GDS-15 indicates Geriatric Depression Scale 15-item questionnaire (range, 0-15; higher scores indicate more severe depressive symptoms; minimal clinically important difference, 2 points).

^aPositive results indicate benefit of placebo.

^bAdjusted for age, sex, GDS-15 score at baseline, levothyroxine dose at baseline, and country.